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Cidara Therapeutics Announces Presentations at the 8th Advances Against Aspergillosis Conference and 2018 BMT Tandem Meeting
“Cidara’s presentations at these two important conferences highlight our commitment to exploring the full clinical utility of rezafungin with our scientific collaborators,” said
A total of four poster presentations will highlight the efficacy of rezafungin against serious invasive fungal infections (IFIs), including Candida, Aspergillus and Pneumocystis infections. These infections are especially relevant for patients whose immune systems have been compromised, such as patients undergoing bone marrow transplantation (BMT) or chemotherapy. IFIs are also a significant cause of morbidity and mortality in patients with hematologic malignancies. The 90-day mortality rate in patients who have a hematologic malignancy or undergo BMT and are then diagnosed with an IFI ranges from 52 to 63 percent.
Specifically, presented data will demonstrate the following potential advantages of rezafungin as compared to the current antifungal standard of care: in vitro activity against azole-resistant Aspergillus; the high concentrations of rezafungin distributing into the lungs; and the rationale for dose selection for the prevention of Aspergillus, Candida and Pneumocystis infections in BMT patients.
Details of the Cidara AAA and BMT Tandem Meetings presentations are as follows:
2018 BMT Tandem Meetings Presentations (
Copies of these posters and presentations will be available on the Cidara website following the meetings: www.cidara.com.
About Invasive Fungal Infections
Invasive fungal infections (IFIs) represent a serious threat to millions of patients worldwide, resulting in more than 1.5 million deaths annually and mortality rates ranging from 15 to 65 percent. These infections continue to be a global health issue, especially for critically ill patients in hospitals and patients with compromised immune systems. Of the most significant IFIs, approximately 90 percent of related deaths are primarily caused by Candida, Aspergillus, and Pneumocystis. Candida species are most common in hospital-acquired infections, while Aspergillus species are predominant in patients with weakened immune systems or lung diseases. Pneumocystis infections also commonly afflict immunocompromised patients.
Cidara is a clinical-stage biotechnology company focused on developing new anti-infectives that have the potential to transform the standard of care and save or improve patients’ lives. The company is currently advancing its novel echinocandin antifungal, rezafungin acetate, formerly called CD101 IV, through Phase 2 and developing CD201, its bispecific antibiotic immunotherapy, for the treatment of multi-drug resistant Gram-negative bacterial infections. Rezafungin has improved pharmacokinetics compared to existing echinocandins and has the potential for expanded utility across patient settings. Rezafungin is the only once-weekly product candidate in development for the treatment and prevention of life-threatening invasive fungal infections. CD201 is the first drug candidate selected from Cidara’s novel Cloudbreak™ platform, the first immunotherapy discovery platform designed specifically to create compounds that directly kill pathogens and also direct a patient’s immune cells to attack and eliminate bacterial, fungal or viral pathogens. Cidara has received a grant for up to
Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, the effectiveness, safety, and other attributes of rezafungin and other potential product candidates, including the potential for these compounds to successfully treat or prevent infections, including those caused by resistant pathogens, and augment treatment and prophylaxis strategies in the future, and the potential for rezafungin to have advantages over the current standard of care in the treatment or prevention of invasive fungal infections. Risks that contribute to the uncertain nature of the forward-looking statements include: the success and timing of Cidara’s preclinical studies and clinical trials; regulatory developments in