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Newly Published Journal of Antimicrobial Chemotherapy Supplement Provides Insights into the Future of Echinocandin Therapy for Invasive Fungal Infections

Authors Highlight How New Options Can be Used to Augment Antifungal Treatment and Prophylaxis Strategies

SAN DIEGO, Jan. 04, 2018 (GLOBE NEWSWIRE) -- Cidara Therapeutics, Inc. (Nasdaq:CDTX), a biotechnology company developing novel anti-infectives including immunotherapies, today announced that a new compendium of papers published as a Journal of Antimicrobial Chemotherapy supplement reviews evidence and provides insights into the future of echinocandin therapy, including strategies for the treatment and prevention of life-threatening invasive fungal infections.  

“Fungal infections are an important cause of morbidity and mortality worldwide, in particular among the expanding population of immunosuppressed and elderly patients, prompting a serious review of our current therapeutic approaches and the development of new options,” said Matteo Bassetti, M.D., guest editor of Journal of Antimicrobial Chemotherapy and head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital, Udine, Italy. “This newly published compendium of papers presents perspectives on how the current use of echinocandin antifungals can be improved and how newer options would augment treatment and prophylaxis strategies in the future, especially in a world of increasing patient complexity.”

The supplement, titled “The Future of Echinocandin Therapy," can be downloaded here. It is comprised of nine papers authored by Dr. Bassetti and other experts from Europe and North America who worked independently to review the latest evidence and examine the latest in practice and research, leading echinocandins into the future of antifungal treatment and prophylaxis. The authors selected and covered the most critical aspects facing them in clinical practice and research, including: antifungal drug safety and toxicities, pharmacokinetics, novel antifungal agents in development, and therapy and prevention among a complex and diverse patient population (including patients in the ICU, patients with cancer, and patients undergoing transplant).  

About Invasive Fungal Infections

Fungal infections can carry a mortality rate of 35-50 percent, higher than most bacterial infections. Approximately 97,000 Americans die from hospital-related fungal infections each year and 90 percent of these infections are caused by two common fungi, Candida and Aspergillus. These infections represent a significant public health issue, particularly in highly vulnerable patient populations at risk for infection, such as the elderly, post-surgical, critically ill and other hospitalized patients with serious medical conditions. There is an urgent and growing need for new therapeutic approaches to treat and prevent serious invasive fungal infections.

About Cidara Therapeutics

Cidara is a clinical-stage biotechnology company focused on developing new anti-infectives that have the potential to transform the standard of care and save or improve patients’ lives. The company is currently advancing its novel echinocandin antifungal, rezafungin acetate, formerly called CD101 IV, through Phase 2 and developing CD201, its bispecific antibiotic immunotherapy, for the treatment of multi-drug resistant Gram-negative bacterial infections. Rezafungin has improved pharmacokinetics compared to existing echinocandins and has the potential for expanded utility across patient settings. Rezafungin is the only once-weekly product candidate in development for the treatment and prevention of life-threatening invasive fungal infections. CD201 is the first drug candidate selected from Cidara’s novel Cloudbreak™ platform, the first immunotherapy discovery platform designed specifically to create compounds that directly kill pathogens and also direct a patient’s immune cells to attack and eliminate bacterial, fungal or viral pathogens. Cidara has received a grant for up to $6.9 million from CARB-X (Combating Antibiotic Resistant Bacteria Accelerator) to advance the development of CD201 and back-up molecules. Cidara is headquartered in San Diego, California. For more information, please visit

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the anticipated timing of topline data for the STRIVE trial, the effectiveness, safety, and other attributes of rezafungin and other potential product candidates, including the potential for these compounds to successfully treat or prevent infections, including those caused by resistant pathogens, and augment treatment and prophylaxis strategies in the future, the design and timing of rezafungin Phase 3 clinical trials, the potential for CD201 to successfully treat or prevent infections and the potential for the Cloudbreak platform to result in future drug candidates. Risks that contribute to the uncertain nature of the forward-looking statements include: the success and timing of Cidara’s preclinical studies and clinical trials; regulatory developments in the United States and foreign countries; changes in Cidara’s plans to develop and commercialize its product candidates; Cidara’s ability to obtain additional financing; Cidara’s ability to obtain and maintain intellectual property protection for its product candidates; and the loss of key scientific or management personnel. These and other risks and uncertainties are described more fully in Cidara’s Form 10-Q most recently filed with the United States Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Cidara undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

Robert H. Uhl
Westwicke Partners, LLC
Managing Director
(858) 356-5932

Christy Curran
Sam Brown Inc.

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Cidara Therapeutics, Inc.